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The effects of external beam irradiation on the growth of flat bones in children: Modeling a dose-volume effect by Matthew J. Krasin; Xiaoping Xiong; Shengjie Wu; Thomas E. Merchant is a Medicine article available to read on EtoBox.

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Purpose: To model the effects of external beam irradiation on the developing flat bones of pediatric patients undergoing radiation therapy (RT) for tumors involving the musculoskeletal system. Methods and Materials: Patients with image-guided RT plans including areas adjacent to facial or pelvic flat bones underwent retrospective contouring of nontumor involved flat bones ipsilateral and contralateral to the treatment side. Radiation dose-volume information and bone volume data (initial and the most recent follow-up) were analyzed in 15 paired flat bones from 10 patients (ages 1.0 -17.0 years). The models to predict bone growth after completion of RT (v post ) were based on initial bone volume (v pre ), the patient's age, time to follow-up (t), and the dose-volume parameter (v Int35؉ ). Results: We developed a dose effects model as follows: Log (v post / v pre ) ‫؍‬ ␤ time t ؉ ␤ age group t ؉ ␤ dose t v Int35 . The dose-volume parameter v Int35 predicted significantly for alterations in growth in younger patients, but not for older patients. The predictability of the fitted model for relative change in bone growth improved in the younger age group with the addition of the dose-volu

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Author

Matthew J. Krasin; Xiaoping Xiong; Shengjie Wu; Thomas E. Merchant

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2005

Language

EN

Field

Medicine (Health Sciences)