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Natural programmed cell death in T. cruzi epimastigotes maintained in axenic cultures by V. Jimenez; R. Paredes; M.A. Sosa; N. Galanti is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Natural programmed cell death in T. cruzi epimastigotes maintained in axenic cultures about?

## Abstract __Trypanosoma cruzi__, a parasitic protozoan, is the agent of Chagas' disease or American trypanosomiasis, an endemic pathology in Latin America, affecting up to 18 million people, with high public health costs. Programmed cell death (PCD) has many functions in development and tissue remodeling in metazoans. In protozoa, it could represent concomitant or alternative mechanisms for clonal selection, immune response evasion, and population size regulation. In this work, we describe the natural occurrence of PCD in __T. cruzi__ epimastigotes during the stationary phase of growth in axenic culture or under nutrient deprivation. Thus, we have observed phosphatidylserine externalization, cellular volume decrease, caspase‐like protein activity, and DNA fragmentation. Additionally, serum deprivation also induces autophagic characteristics such as monodansylcadaverine‐labeled vesicles accumulation and redistribution of proteins homologous to Atg8. In agreement with our results, apoptosis may play an important role in parasite survival. Then, identification and modulation of molecular targets inducing programmed cell death in __T. cruzi__ may lead to new potential therapeutic app

Who reads Natural programmed cell death in T. cruzi epimastigotes maintained in axenic cultures?

Author

V. Jimenez; R. Paredes; M.A. Sosa; N. Galanti

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)