Can I read Effect of dendritic cell–based immunotherapy on hepatocellular carcinoma: A systematic review and meta-analysis on EtoBox?

Effect of dendritic cell–based immunotherapy on hepatocellular carcinoma: A systematic review and meta-analysis by CONG CHEN; YIN-HUA MA; YA-TING ZHANG; FAN ZHANG; NING ZHOU; XIANG WANG; TAO LIU; YU-MIN LI is a Medicine article available to read on EtoBox.

What is Effect of dendritic cell–based immunotherapy on hepatocellular carcinoma: A systematic review and meta-analysis about?

## Background aims: Dendritic cell (dc)-based immunotherapy has recently been reported frequently in the treatment of hepatocellular carcinoma (hcc); however, its efficacy remains controversial. in this study, we aimed to evaluate the clinical efficacy of dc-based immunotherapy on hcc by conducting a systematic review and meta-analysis. ## Methods: Pubmed, cochrane library, embase and web of science were searched to identify clinical trials on dc-based immunotherapy for hcc published up to january 31, 2018. the articles were selected according to pre-established inclusion criteria and methodologic quality, and publication bias were evaluated. ## Results: A total of 1276 cases from 19 clinical trials were included. compared with traditional treatment, further dc-based therapy enhanced the cd4 t/cd8 t ratio (standardized mean difference: 0.68, 95% confidence interval [ci] 0.46-0.89, p 1, p < 0.05), prolonged the median pfs time (median survival ratio [msr]: 1.98, 95% ci: 1.60-2.46, p < 0.001) and median os time (msr: 1.72, 95% ci: 1.51-1.96, p < 0.001). adverse reactions were mild. ## Conclusions: Dc-based therapy not only enhanced anti-tumor immunity, improved the survival rate an

Who reads Effect of dendritic cell–based immunotherapy on hepatocellular carcinoma: A systematic review and meta-analysis?

Author

CONG CHEN; YIN-HUA MA; YA-TING ZHANG; FAN ZHANG; NING ZHOU; XIANG WANG; TAO LIU; YU-MIN LI

Published

2018

Language

EN

Field

Medicine (Health Sciences)