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Engineering Fibrin Polymers Through Engagement of Alternative Polymerization Mechanisms by Sarah E. Stabenfeldt; Merek Gourley; Laxminarayanan Krishnan; James B. Hoying; Thomas H. Barker is a Engineering article available to read on EtoBox.

What is Engineering Fibrin Polymers Through Engagement of Alternative Polymerization Mechanisms about?

Fibrin is an attractive material for regenerative medicine applications. It not only forms a polymer but also contains cryptic matrikines that are released upon its activation/degradation and enhance the regenerative process. Despite this advantageous biology associated with fibrin, commercially available systems (e.g. TISSEEL) display limited regenerative capacity. This limitation is in part due to formulations that are optimized for tissue sealant applications and result in dense fibrous networks that limit cell infiltration. Recent evidence suggests that polymerization knob 'B' engagement of polymerization hole 'b' activates an alternative polymerization mechanism in fibrin, which may result in altered single fiber mechanical properties. We hypothesized that augmenting fibrin polymerization through the addition of PEGylated knob peptides with specificity to hole 'b' (AHRPYAAC-PEG) would result in distinct fibrin polymer architectures with grossly different physical properties. Polymerization dynamics, polymer architecture, diffusivity, viscoelasticity, and degradation dynamics were analyzed. Results indicate that specific engagement of hole 'b' with PEGylated knob 'B' conjugates

Who reads Engineering Fibrin Polymers Through Engagement of Alternative Polymerization Mechanisms?

Author

Sarah E. Stabenfeldt; Merek Gourley; Laxminarayanan Krishnan; James B. Hoying; Thomas H. Barker

Publisher

Elsevier BV

Published

2012

Language

EN

Field

Engineering (Physical Sciences)