Opening book details…
Can I read Treatment with an Angiopoietin‐1 mimetic peptide promotes neurological recovery after stroke in diabetic rats on EtoBox?
Treatment with an Angiopoietin‐1 mimetic peptide promotes neurological recovery after stroke in diabetic rats by Venkat, Poornima; Ning, Ruizhuo; Zacharek, Alex; Culmone, Lauren; Liang, Linlin; LandschootâWard, Julie; Chopp, Michael is a Neuroscience article available to read on EtoBox.
What is Treatment with an Angiopoietin‐1 mimetic peptide promotes neurological recovery after stroke in diabetic rats about?
## Aim: Vasculotide (vt), an angiopoietin-1 mimetic peptide, exerts neuroprotective effects in type one diabetic (t1dm) rats subjected to ischemic stroke. in this study, we investigated whether delayed vt treatment improves long-term neurological outcome after stroke in t1dm rats. ## Methods: Male wistar rats were induced with t1dm, subjected to middle cerebral artery occlusion (mcao) model of stroke, and treated with pbs (control), 2 μg/kg vt, 3 μg/kg vt, or 5.5 μg/kg vt. vt treatment was initiated at 24 h after stroke and administered daily (i.p) for 14 days. we evaluated neurological function, lesion volume, vascular and white matter remodeling, and inflammation in the ischemic brain. in vitro, we evaluated the effects of vt on endothelial cell capillary tube formation and inflammatory responses of primary cortical neurons (pcn) and macrophages. ## Results: Treatment of t1dm-stroke with 3 μg/kg vt but not 2 μg/kg or 5.5 μg/kg significantly improves neurological function and decreases infarct volume and cell death compared to control t1dm-stroke rats. thus, 3 μg/kg vt dose was employed in all subsequent in vivo analysis. vt treatment significantly increases axon and myelin densit
Who reads Treatment with an Angiopoietin‐1 mimetic peptide promotes neurological recovery after stroke in diabetic rats?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Venkat, Poornima; Ning, Ruizhuo; Zacharek, Alex; Culmone, Lauren; Liang, Linlin; LandschootâWard, Julie; Chopp, Michael
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley (ISSN 1755-5930)
- Published
- 2020
- Language
- EN
- Field
- Neuroscience (Life Sciences)