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Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells by Umadevi V. Wesley; Shakuntala Tiwari; Alan N. Houghton is a Medicine article available to read on EtoBox.

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## Abstract Lung cancer is the leading cause of cancer death. Lung cancers produce a variety of mitogenic growth factors that stimulate tumor cell proliferation and migration. The cell surface protease, dipeptidyl peptidase IV (DPPIV), is involved in diverse biologic functions, including peptide‐mediated cellular growth and differentiation. DPPIV is expressed in various normal tissues, including lung tissue, and its expression is lost in many types of human cancers. DPPIV expression and its enzymatic activity are detected in normal bronchial and alveolar epithelium but different histologic subtypes of lung carcinomas lose DPPIV expression. To investigate the role of DPPIV in lung carcinoma, we examined the expression of DPPIV at both mRNA and protein levels in non small cell lung cancer (NSCLC) cell lines and normal human bronchial epithelial cells. DPPIV expression was detectable in normal lung epithelial cells, but was absent or markedly reduced in all NSCLC cell lines at both mRNA and protein levels. Restoration of DPPIV expression in NSCLC cells resulted in profound morphologic changes, inhibition of cell proliferation, anchorage‐independent growth, __in vitro__ cell migration

Who reads Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells?

Author

Umadevi V. Wesley; Shakuntala Tiwari; Alan N. Houghton

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2004

Language

EN

Field

Medicine (Health Sciences)