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Can I read D-mannose Ameliorates Autoimmune Phenotypes in Mouse Models of Lupus on EtoBox?
D-mannose Ameliorates Autoimmune Phenotypes in Mouse Models of Lupus by Wang, Haiting ;Teng, Xiangyu ;Abboud, Georges ;Li, Wei ;Ye, Shuang ;Morel, Laurence is a Immunology and Microbiology article available to read on EtoBox.
What is D-mannose Ameliorates Autoimmune Phenotypes in Mouse Models of Lupus about?
## Abstract ## Background Systemic lupus erythematosus is an autoimmune disease characterized by an overproduction of autoantibodies resulting from dysregulation in multiple immune cell types. D-mannose is a C^− 2^ epimer of glucose that exhibits immunoregulatory effects in models of autoimmune diseases, such as type 1 diabetes, induced rheumatoid arthritis, and airway inflammation. This study was conducted to evaluate the efficacy of D-mannose treatment in mouse models of lupus. ## Results Firstly, the effect of D-Mannose was evaluated by flow cytometry on the in vitro activation of non-autoimmune C57BL/6 (B6) bone marrow-derived dendritic cells (BMDCs) and their ability to induce antigen-specific CD4^+^ T cell proliferation and activation. D-mannose inhibited the maturation of BMDCs and their induction of antigen-specific T cell proliferation and activation. In vivo, D-mannose increased the frequency of Foxp3^+^ regulatory T cells in unmanipulated B6 mice. To assess the effect of D-mannose in mouse models of lupus, we used the graft-versus-host disease (cGVHD) induced model and the B6.lpr spontaneous model. In the cGVHD model, D-mannose treatment decreased autoantibody production
Who reads D-mannose Ameliorates Autoimmune Phenotypes in Mouse Models of Lupus?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Wang, Haiting ;Teng, Xiangyu ;Abboud, Georges ;Li, Wei ;Ye, Shuang ;Morel, Laurence
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)