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Can I read Cell response of cultured macrophages, fibroblasts, and co-cultures of Kupffer cells and hepatocytes to particles of short-chain poly[(R)-3-hydroxybutyric acid] on EtoBox?
Cell response of cultured macrophages, fibroblasts, and co-cultures of Kupffer cells and hepatocytes to particles of short-chain poly[(R)-3-hydroxybutyric acid] by B. Saad; G. Ciardelli; S. Matter; M. Welti; G. K. Uhlschmid; P. Neuenschwander; U. W. Suter is a Engineering article available to read on EtoBox.
What is Cell response of cultured macrophages, fibroblasts, and co-cultures of Kupffer cells and hepatocytes to particles of short-chain poly[(R)-3-hydroxybutyric acid] about?
The known biodegradability of poly[(R)-3-hydroxybutyric acid] (PHB) in certain biological environments has lead to its proposed use as biodegradable, biocompatible polymer. Recently, a new, rapidly biodegradable blockcopolymer has been synthesized that contains crystalline domains of PHB blocks. During degradation of these polymers, the PHB-domains are transformed in a first step into small crystalline particles of short-chain PHB. Therefore, particles of short-chain poly[(R)-3-hydroxybutyric acid] (Mn ~ 2300) (PHB-P), as possible degradation products, are investigated here for their effects on the viability and activation of macrophages, fibroblasts, and co-cultures of rat Kupffer cells and rat hepatocytes. Results obtained in the present study indicate that phagocytosis of particles of short-chain poly[(R)-3-hydroxybutyric acid] at high concentrations (higher than 10 pg/ml) is dosedependent and associated with cell damage in macrophages but not in fibroblasts. At low concentrations, particles of PHB-P also failed to activate macrophages and are biocompatible. Besides the PHB phagocytosis by Kupffer cells, treatment of co-cultures of Kupffer cells and hepatocytes with 1 ~tg PHB/ml
Who reads Cell response of cultured macrophages, fibroblasts, and co-cultures of Kupffer cells and hepatocytes to particles of short-chain poly[(R)-3-hydroxybutyric acid]?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- B. Saad; G. Ciardelli; S. Matter; M. Welti; G. K. Uhlschmid; P. Neuenschwander; U. W. Suter
- Publisher
- Springer; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC (ISSN 0957-4530)
- Published
- 1996
- Language
- EN
- Field
- Engineering (Physical Sciences)