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Analysis of Cell Growth in a Polymer Scaffold Using a Moving Boundary Approach by Craig J. Galban; Bruce R. Locke is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Analysis of Cell Growth in a Polymer Scaffold Using a Moving Boundary Approach about?

Two mathematical models of chondrocyte generation and nutrient consumption are developed to analyze the behavior of cell growth in a biodegradable polymer matrix. Substrate reaction and diffusion are analyzed in two regions: one consisting of cells and nutrients and the other consisting of only nutrients. A pseudosteady state approximation for the transport of nutrients in these two regions is utilized. The rate of growth is determined by a moving boundary equation that equates the rate at which the interfacial region between the cells and the void space moves to a substrate dependent growth reaction. The change in the location of this interfacial region with time therefore depicts the rate at which the cells propagate. The two limiting cases discussed in this article represent extremes in how the cells will grow in the polymer matrix; one case assumes that cells grow inward from the external boundary, and the other case assumes that cells grow parallel to the external boundary. The results of both models are compared to experimental data found in the literature. It is found through these comparisons that the model parameters, including the unit cell spacing parameter L, the metabo

Who reads Analysis of Cell Growth in a Polymer Scaffold Using a Moving Boundary Approach?

Author

Craig J. Galban; Bruce R. Locke

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley - V C H Verlag GmbbH & Co.; Wiley (ISSN 0006-3592)

Published

1997

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)