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A Randomized Comparison of Atropine and Metaproterenol Inhalational Therapies for Refractory Status Asthmaticus by Gary P Young; Paul Freitas is a Medicine article available to read on EtoBox.

What is A Randomized Comparison of Atropine and Metaproterenol Inhalational Therapies for Refractory Status Asthmaticus about?

To compare the forced expiratory volume in one second (FEV~) response to inhaled anticholinergic with the response to ~-adrenergic solutions in adults with refractory status asthmaticus. Design: After the decision was made to hospitalize, 40 patients were prospectively randomized in a double-blind trial to receive either atropine sulfate or metaproterenoI by nebulizer. Setting: A county teaching hospital emergency department. Type of participants: Adults requiring hospitalization for refractory status asthmaticus. Interventions: Standard therapies for acute bronchospasm, followed by either 1.5 mg atropine or I5 mg metaproterenol by nebulizer. Measurements and main results: The two groups were similar on entry into the study, including mean FEV l measurements (0. 70 L atropine~0.60 L metaproterenol, P > .05). Compared with baseline, the FEV 1 improvement for the metaproterenol group was statistically significant (+0.18 L, P = .05; +31%, P .05). Comparing the two groups, statistically significant differences favoring metaproterenol were found in the percent improvement in the FEVI (+10% atropine~+31% metaproterenol, P < .05) and in the percentage of patients experiencing at least a

Who reads A Randomized Comparison of Atropine and Metaproterenol Inhalational Therapies for Refractory Status Asthmaticus?

Author

Gary P Young; Paul Freitas

Publisher

Elsevier Science; Elsevier ; Mosby Inc.; Elsevier BV (ISSN 1097-6760)

Published

1991

Language

EN

Field

Medicine (Health Sciences)