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Polymorphisms at p53, p73, and MDM2 loci modulate the risk of tobacco associated leukoplakia and oral cancer by Chaitali Misra; Mousumi Majumder; Swati Bajaj; Saurabh Ghosh; Bidyut Roy; Susanta Roychoudhury is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Polymorphisms at loci controlling cellular processes such as cell cycle, DNA repair, and apoptosis may modulate the risk of cancer. We examined the association of two linked polymorphisms (G4C14–A4T14) at __p73__ and one polymorphism (309G > T) at __MDM2__ promoter with the risk of leukoplakia and oral cancer. The __p73__ and __MDM2__ genotypes were determined in 197 leukoplakia patients, 310 oral cancer patients and in 348 healthy control subjects. The __p73 GC__/__AT__ genotype increased the risk of leukoplakia (OR = 1.6, 95% CI = 1.1–2.3) and oral cancer (OR = 2.4, 95% CI = 1.7–3.3) but the 309G > T __MDM2__ polymorphism independently could not modify the risk of any of the diseases. Stratification of the study population into subgroups with different tobacco habits showed that the risk of the oral cancer is not modified further for the individuals carrying __p73__ risk genotype. However, leukoplakia patients with smokeless tobacco habit showed increased risk with combined GC/AT and AT/AT (OR = 3.0, 95% CI = 1.3–7.0) genotypes. A combined analysis was done with our previous published data on __p53__ codon 72 pro/arg polymorphism. Analysis of pair wise genotype combin

Who reads Polymorphisms at p53, p73, and MDM2 loci modulate the risk of tobacco associated leukoplakia and oral cancer?

Author

Chaitali Misra; Mousumi Majumder; Swati Bajaj; Saurabh Ghosh; Bidyut Roy; Susanta Roychoudhury

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)