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Sirtuin 1 Deficiency Decreases Bone Mass and Increases Bone Marrow Adiposity in a Mouse Model of Chronic Energy Deficiency by Louvet, Loà̄c; Leterme, Damien; Delplace, Séverine; Miellot, Flore; Marchandise, Pierre; Gauthier, Véronique; Hardouin, Pierre; Chauveau, Christophe; Ghali Mhenni, Olfa is a Medicine article available to read on EtoBox.

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Sirtuin of type 1 (Sirt1), a class III HDAC, is known to be involved in the regulation of differentiation of skeletal stem cells (SSCs) into osteoblasts and adipocytes. In caloric restriction, it has been shown that the expression and activity of Sirt1 is a tissue-dependent regulation. However, at present, no study has focused on the link between Sirt1, bone marrow adiposity (BMA) and osteoporosis related to anorexia nervosa (AN). Thus, the aims of this work were to (i) determine BMA and bone changes in a mouse model replicating the phenotypes of AN (separation-based anorexia model (SBA)); (ii) determine the expression of Sirt1 in bone marrow stromal cells (BMSCs) extracted from these mice and identify their differentiation capacities; (iii) study the effects of pharmacological activation and inhibition of Sirt1 on the osteoblastogenesis and adipogenesis of these cells and (iiii) delineate the molecular mechanism by which Sirt1 could regulate osteogenesis in an SBA model. Our results demonstrated that SBA protocol induces an increase in BMA and alteration of bone architecture. In addition, BMSCs from restricted mice present a down-regulation of Sirt1 which is accompanied by an incr

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Author

Louvet, Loà̄c; Leterme, Damien; Delplace, Séverine; Miellot, Flore; Marchandise, Pierre; Gauthier, Véronique; Hardouin, Pierre; Chauveau, Christophe; Ghali Mhenni, Olfa

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 8756-3282)

Published

2020

Language

EN

Field

Medicine (Health Sciences)