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PAX3/7 expression coincides with myod during chronic skeletal muscle overload by Jon-Philippe K. Hyatt; Gary E. McCall; Elizabeth M. Kander; Hui Zhong; Roland R. Roy; Kimberly A. Huey is a Medicine article available to read on EtoBox.
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## Abstract Paired box (Pax) proteins 3 and 7 are key determinants for embryonic skeletal muscle development by initiating myogenic regulatory factor (MRF) gene expression. We show that Pax3 and 7 participate in adult skeletal muscle plasticity during the initial responses to chronic overload (≤7 days) and appear to coordinate MyoD expression, a member of the MRF family of genes. Pax3 and 7 mRNA were higher than control within 12 h after initiation of overload, preceded the increase in MyoD mRNA on day 1, and peaked on day 2. On days 3 and 7, Pax7 mRNA remained higher than control, suggesting that satellite cell self‐renewal was occurring. Pax3 and 7 and MyoD protein levels were higher than control on days 2 and 3. These data indicate that Pax3 and 7 coordinate the recapitulation of developmental‐like regulatory mechanisms in response to growth‐inducing stimuli in adult skeletal muscle, presumably through activation of satellite cells. Muscle Nerve, 2008
Who reads PAX3/7 expression coincides with myod during chronic skeletal muscle overload?
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- Author
- Jon-Philippe K. Hyatt; Gary E. McCall; Elizabeth M. Kander; Hui Zhong; Roland R. Roy; Kimberly A. Huey
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0148-639X)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)