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Characterization of CD8‐positive macrophages infiltrating the central nervous system of rats with chronic autoimmune encephalomyelitis by Keiko Hiraki; Il‐Kwon Park; Kuniko Kohyama; Yoh Matsumoto is a Neuroscience article available to read on EtoBox.

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## Abstract CD8^+^ macrophages appear in the central nervous system (CNS) under various pathological conditions such as trauma and ischemia. Furthermore, macrophages expressing CD8 were found in CNS lesions of chronic, but not acute, experimental autoimmune encephalomyelitis (EAE). To further characterize cells with this phenotype, we examined CD8^+^ macrophages/monocytes in the CNS and peripheral organs during the course of acute and chronic EAE that had been induced by immunization of rats with myelin basic protein and myelin oligodendrocyte glycoprotein, respectively. Counting CD8^+^ macrophages in CNS lesions revealed that their numbers increased reaching about 60% of total infiltrating macrophages in chronic EAE, while CD8^+^ macrophages remained less than 5% throughout the course of acute EAE. Unexpectedly, however, higher abundance of CD8^+^ monocytes/macrophages in the peripheral blood was found in both acute and chronic EAE. Real‐time polymerase chain reaction analysis revealed no significant difference in the levels of chemokines and chemokine receptors of blood CD8^+^ monocytes between acute and chronic EAE. mRNA expression of perforin, a cytotoxic substance, was up‐regu

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Author

Keiko Hiraki; Il‐Kwon Park; Kuniko Kohyama; Yoh Matsumoto

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

2008

Language

EN

Field

Neuroscience (Life Sciences)