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Spray Drying as an Efficient Route for Synthesis of Silica Nanoparticles-sodium Alginate Biohybrid Drug Carrier of Doxorubicin by Archana Mishra; Vipul K. Pandey; Bhavani S. Shankar; Jose S. Melo is a Materials Science article available to read on EtoBox.

What is Spray Drying as an Efficient Route for Synthesis of Silica Nanoparticles-sodium Alginate Biohybrid Drug Carrier of Doxorubicin about?

Biohybrids (a combination of biological material and inorganic nanoparticles) offer a number of advantages like improved functionality over conventional materials.Thus, to understand the practical application of biohybrids as drug carriers, a biohybrid drug carrier of colloidal silica nanoparticles (NP)-sodium alginate loaded with doxorubicin (Dox-biohybrid) was synthesized by evaporation induced self-assembly (EISA) using spray drying technique. Further, the morphology, size and interactions between various components of the biohybrid were studied through SEM, DLS and FTIR techniques. The drug loading efficiency, release profile, cellular uptake and cytotoxicity of Dox-biohybrid was investigated and compared with free Dox. The drug loading efficiencies of Dox-biohybrid, Dox-silica NP and Dox-sodium alginate were 93.7 %, 96.4 % and 88.3 % respectively. In vitro release study showed a slow release of entrapped Dox from Dox-biohybrid as compared to other carriers. This release was also pH-responsive with significantly higher cumulative drug release at pH 5.5 (cancer microenvironment) in comparison to pH 7.4 (physiological conditions). The empty biohybrid carrier did not show cytotoxi

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Author

Archana Mishra; Vipul K. Pandey; Bhavani S. Shankar; Jose S. Melo

Published

2020

Language

EN

Field

Materials Science (Physical Sciences)