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Microglia Shape Neural Connectivity by trevorfallon4 is a document available to read on EtoBox.
This study investigates how sensory experience influences neural connectivity in the retinogeniculate circuit through the interaction of Fn14 in relay neurons and TWEAK in microglia. It reveals that visual experience increases Fn14 expression, promoting synapse formation, while TWEAK signaling from microglia can reduce synapse numbers near TWEAK-expressing microglia, indicating a non-phagocytic mechanism of synaptic refinement. The findings highlight the role of microglia in shaping neural circuits during c
- Author
- trevorfallon4
- Language
- EN