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Effect of cyclosporine A and its primary metabolites on circadian blood pressure variation by Petra Halvová1,2, Ivana Kacířová1,2, Hana Brozmanová1,2, Milan Grundmann2 is a scholarly article available to read on EtoBox.

Background: Cyclosporine A (CsA) is a potent immunosuppressive agent used after organ transplantation, including renal transplantation. CsA has also been shown to affect blood pressure (BP) diurnal variation by significantly increasing night-time blood pressure. Tight blood pressure control is a key objective in renal transplant patients, and for this purpose ABPM might be a useful tool. The aim of the study was to compare the relationship between blood and lymphocyte concentrations of CsA and its metabolites in patients with “dipping” or “non-dipping” status. Methods: Thirty-one stable renal transplant patients (16 men, 15 women) were included in this study. The mean patient age was 54 ± 12 years and the mean weight 75 ± 16 kg. Trough (C0) concentrations of CsA and its three metabolites, AM1, AM9, and AM4N, were estimated in blood and lymphocytes using the LC-MS/MS method. All patients underwent ABPM. The patients were divided into two groups: “dippers” (26 measurements) and “non-dippers” (with a nocturnal blood pressure fall < 10%, 25 measurements). GraphPad Prism version 5.00 for Windows was used for statistical analysis. A value of p < 0.05 was considered statistically signific

Author

Petra Halvová1,2, Ivana Kacířová1,2, Hana Brozmanová1,2, Milan Grundmann2

Published

2015