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Can I read Multiparallel Microfluidic High-performance Liquid Chromatography for High-throughput Normal-phase Chiral Analysis on EtoBox?
Multiparallel Microfluidic High-performance Liquid Chromatography for High-throughput Normal-phase Chiral Analysis by Peter Sajonz; Wes Schafer; Xiaoyi Gong; Scott Shultz; Thorsten Rosner; Christopher J. Welch is a Chemistry article available to read on EtoBox.
What is Multiparallel Microfluidic High-performance Liquid Chromatography for High-throughput Normal-phase Chiral Analysis about?
The suitability of the Eksigent Express 800 microfluidic eight-channel HPLC instrument for multiparallel normal-phase chiral analysis in support of high-throughput pharmaceutical process research was investigated. Analysis of test mixtures containing the two enantiomers of benzoin and the closely related (R,S)-dihydrobenzoin, was carried out in a 96-well microplate, affording rapid (<2 h) and accurate assessment of enantiopurity. In a second example, use of the instrument to support high-throughput catalyst screening of the asymmetric hydrogenation of a prochiral unsaturated ester is presented, in which method development (gradient screening of four columns and two eluents, followed by optimization to afford a fast analytical method) and analysis of a 96-well microplate was carried out within a single working day. This represents a considerable improvement over conventional analysis techniques that usually take several days to complete.
Who reads Multiparallel Microfluidic High-performance Liquid Chromatography for High-throughput Normal-phase Chiral Analysis?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Peter Sajonz; Wes Schafer; Xiaoyi Gong; Scott Shultz; Thorsten Rosner; Christopher J. Welch
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)
- Published
- 2007
- Language
- EN
- Field
- Chemistry (Physical Sciences)