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Effect of cocaine self-administration on striatal dopamine D1 receptors in rhesus monkeys by Rodney J. Moore; Sharon L. Vinsant; Michael A. Nader; Linda J. Porrino; David P. Friedman is a Neuroscience article available to read on EtoBox.

What is Effect of cocaine self-administration on striatal dopamine D1 receptors in rhesus monkeys about?

An array of evidence indicates that long-term exposure to cocaine alters several components of the brain dopamine system. Because the release of dopamine in the nucleus accumbens (NAc) has been implicated in mediating the reinforcing effects of cocaine, changes in dopamine function can have profound effects on drug-seeking and drug-taking behavior. The present study examined the effects of the chronic selfadministration of cocaine on the D 1 family of dopamine receptors in the rhesus monkey. The brains of three rhesus monkeys that had intravenously self-administered an average of 1.35 mg/kg cocaine per day for 18-22 months were compared to the brains of three cocaine-naive controls. The in vitro quantitative autoradiographic technique was used to quantify binding densities of the D 1 ligand [ 3 H]SCH-23390 on cryostat-cut sections of fresh frozen tissue. In animals that self-administered cocaine, the density of D 1 binding was significantly lower in the regions of the striatum at the level where the nucleus accumbens is most fully developed. The shell of the NAc showed the largest difference with significantly lower D 1 binding also detected in adjacent regions of the caudate nucle

Who reads Effect of cocaine self-administration on striatal dopamine D1 receptors in rhesus monkeys?

Author

Rodney J. Moore; Sharon L. Vinsant; Michael A. Nader; Linda J. Porrino; David P. Friedman

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)

Published

1997

Language

EN

Field

Neuroscience (Life Sciences)