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Renal Arteriolar Contractile Responses To Angiotensin Ii In Rats With Poorly Controlled Diabetes Mellitus by Pamela K Carmines; Kazuhisa Ohishi is a Medicine article available to read on EtoBox.

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## SUMMARY 1. Experiments were performed to test the hypothesis that renal arteriolar responses to angiotensin (Ang)II are altered in insulin‐dependent diabetes mellitus. 2. Male Sprague‐Dawley rats were treated with streptozotocin (STZ; 65 mg/kg, i.v) or 0.9% NaCl vehicle (Sham). Partial insulin replacement maintained blood glucose levels at 422±6 mg/dL (STZ rats) for the ensuing 2 week period (86±4 mg/dL in Sham rats). The __in vitro__ blood‐perfused juxtamedullary nephron technique was used to study renal arteriolar diameter responses to exogenous AngII or K^+^‐induced membrane depolarization. 3. Baseline afferent arteriolar diameter did not differ between kidneys harvested from Sham and STZ rats; however, constrictor responses to AngII were accentuated in kidneys from diabetic rats. During exposure to 10 nmol/L AngII, afferent diameter decreased by 37±5 and 18±4% in STZ and Sham kidneys, respectively. Efferent arterioles from Sham and STZ rats did not differ with regard to either baseline diameter or AngII responsiveness. 4. In experiments assessing afferent arteriolar responsiveness to membrane depolarization, 40 mmol/L K^+^ decreased lumen diameter by 73±11% in kidneys from S

Who reads Renal Arteriolar Contractile Responses To Angiotensin Ii In Rats With Poorly Controlled Diabetes Mellitus?

Author

Pamela K Carmines; Kazuhisa Ohishi

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0305-1870)

Published

1999

Language

EN

Field

Medicine (Health Sciences)