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Can I read Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling on EtoBox?
Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling by Cemre Celen; Jen-Chieh Chuang; Shunli Shen; Lin Li; Gianna Maggiore; Yuemeng Jia; Xin Luo; Austin Moore; Yunguan Wang; Jordan E. Otto; Clayton K. Collings; Zixi Wang; Xuxu Sun; Ibrahim Nassour; Jiyoung Park; Alexandra Ghaben; Tao Wang; Sam C. Wang; Philipp E. Scherer; Cigall Kadoch; Hao Zhu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling about?
The dynamic regulation of β-cell abundance is poorly understood. Since chromatin remodeling plays critical roles in liver regeneration, these mechanisms could be generally important for regeneration in other tissues. Here, we show that the ARID1A mammalian SWI/SNF complex subunit is a critical regulator of β-cell regeneration. Arid1a is highly expressed in quiescent β-cells but is physiologically suppressed when β-cells proliferate during pregnancy or after pancreas resection. Whole-body Arid1a knockout mice are protected against streptozotocin-induced diabetes. Cell-type and temporally specific genetic dissection show that β-cell-specific Arid1a deletion can potentiate β-cell regeneration in multiple contexts. Transcriptomic and epigenomic profiling of mutant islets reveal increased neuregulin-ERBB-NR4A signaling. Chemical inhibition of ERBB or NR4A1 blocks increased regeneration associated with Arid1a loss. Mammalian SWI/SNF (mSWI/SNF) complex activity is a barrier to β-cell regeneration in physiologic and disease states.
Who reads Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Cemre Celen; Jen-Chieh Chuang; Shunli Shen; Lin Li; Gianna Maggiore; Yuemeng Jia; Xin Luo; Austin Moore; Yunguan Wang; Jordan E. Otto; Clayton K. Collings; Zixi Wang; Xuxu Sun; Ibrahim Nassour; Jiyoung Park; Alexandra Ghaben; Tao Wang; Sam C. Wang; Philipp E. Scherer; Cigall Kadoch; Hao Zhu
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)