Can I read Interleukin-1β Inhibitors for the Management of Acute Gout Flares: a Systematic Literature Review on EtoBox?

Interleukin-1β Inhibitors for the Management of Acute Gout Flares: a Systematic Literature Review by Naomi Schlesinger; Michael H. Pillinger; Lee S. Simon; Peter E. Lipsky is a Medicine article available to read on EtoBox.

What is Interleukin-1β Inhibitors for the Management of Acute Gout Flares: a Systematic Literature Review about?

## Objectives The objective of this systematic review was to assess the effects of interleukin-1β (IL-1β) inhibitors on gout flares. ## Methods Studies published between 2011 and 2022 that evaluated the effects of IL-1β inhibitors in adult patients experiencing gout flares were eligible for inclusion. Outcomes including pain, frequency and intensity of gout flares, inflammation, and safety were assessed. Five electronic databases (Pubmed/Medline, Embase, Biosis/Ovid, Web of Science and Cochrane Library) were searched. Two independent reviewers performed study screening, data extraction and risk of bias assessments (Cochrane Risk of Bias Tool 2 for randomised controlled trials [RCTs] and Downs and Black for non-RCTs). Data are reported as a narrative synthesis. ## Results Fourteen studies (10 RCTs) met the inclusion criteria, with canakinumab, anakinra, and rilonacept being the three included IL-1β inhibitors. A total of 4367 patients with a history of gout were included from the 14 studies (__N__ = 3446, RCTs; __N__ = 159, retrospective studies [with a history of gout]; __N__ = 762, post hoc analysis [with a history of gout]). In the RCTs, canakinumab and rilonacept were reported t

Who reads Interleukin-1β Inhibitors for the Management of Acute Gout Flares: a Systematic Literature Review?

Author

Naomi Schlesinger; Michael H. Pillinger; Lee S. Simon; Peter E. Lipsky

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)