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Substituted Salicylic Acid Analogs Offer Improved Potency Against Multidrug Resistant and Good Selectivity Against Commensal Vaginal Bacteria by skbansal2003 is a document available to read on EtoBox.
This study identifies substituted salicylic acid analogs that exhibit improved antibacterial potency against multidrug-resistant Neisseria gonorrhoeae while maintaining selectivity against commensal vaginal bacteria. Notably, compounds 3b, 3o, and 3p demonstrated superior activity compared to salicylic acid, effectively inhibiting resistant strains with high tolerability to mammalian cells. The findings underscore the urgent need for novel therapeutics in response to the growing threat of untreatable gonoco
- Author
- skbansal2003
- Language
- EN