Can I read Maternal Autoimmune Diseases and Immunologically Induced Embryonic and Fetoplacental Damage on EtoBox?

Maternal Autoimmune Diseases and Immunologically Induced Embryonic and Fetoplacental Damage by Asher Ornoy; Limor Chen; Robert M. Silver; Richard K. Miller is a Medicine article available to read on EtoBox.

What is Maternal Autoimmune Diseases and Immunologically Induced Embryonic and Fetoplacental Damage about?

## Abstract ## BACKGROUND Autoimmune diseases are a group of illnesses in which autoantibodies are produced against various organs, presenting with a variety of clinical symptoms. In this review, we discuss the different aspects of autoimmune diseases in pregnancy. We also describe experimental models that help to understand the etiology and pathogenesis of the effects of this maternal disease on the developing embryo, fetus and placenta. ## METHODS The possible direct effects of sera or IgG obtained from women with systemic lupus erythematosus/antiphospholipid syndrome (SLE/APS) and recurrent pregnancy loss (RPL) were examined on cultured 10.5‐ and 11.5‐day‐old rat embryos and on cultured human placental explants, as compared to sera from healthy women or synthetic medium that were used as controls. In addition, we examined the effects of the sera obtained from these women after successful treatment that allowed the birth of normal infants. ## RESULTS We observed increased embryonic death and anomalies in embryos cultured on sera and IgG from SLE/APS women. Similarly, when human placental explants were cultured on these sera, trophoblastic cell growth was reduced and apoptotic rat

Who reads Maternal Autoimmune Diseases and Immunologically Induced Embryonic and Fetoplacental Damage?

Author

Asher Ornoy; Limor Chen; Robert M. Silver; Richard K. Miller

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1542-0752)

Published

2004

Language

EN

Field

Medicine (Health Sciences)