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Physical and Biological Properties of a Chitosan Hydrogel Scaffold Associated to Photobiomodulation Therapy for Dental Pulp Regeneration: An In Vitro and In Vivo Study by Maria Stella Moreira; Giovanna Sarra; Giovanna Lopes Carvalho; Flavia Gonçalves; Hector Valentin Caballero-Flores; Ana Clara Fagundes Pedroni; Cesar Angelo Lascala; Luiz Henrique Catalani; Márcia Martins Marques is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Physical and Biological Properties of a Chitosan Hydrogel Scaffold Associated to Photobiomodulation Therapy for Dental Pulp Regeneration: An In Vitro and In Vivo Study about?

Background. The regeneration of dental pulp, especially in cases of pulp death of immature teeth, is the goal of the regenerative endodontic procedures (REPs) that are based on tissue engineering principles, consisting of stem cells, growth factors, and scaffolds. Photobiomodulation therapy (PBMT) showed to improve dental pulp regeneration through cell homing approaches in preclinical studies and has been proposed as the fourth element of tissue engineering. However, when a blood clot was used as a scaffold in one of these previous studies, only 30% of success was achieved. The authors pointed out the instability of the blood clot as the regeneration shortcoming. Then, to circumvent this problem, a new scaffold was developed to be applied with the blood clot. The hypothesis of the present study was that an experimental injectable chitosan hydrogel would facilitate the three-dimensional spatial organization of endogenous stem cells in dental pulp regeneration with no interference on the positive influence of PBMT. Methods. For the in vitro analysis, stem cells from the apical papilla (SCAPs) were characterized by flow cytometry and applied in the chitosan scaffold for evaluating adh

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Author

Maria Stella Moreira; Giovanna Sarra; Giovanna Lopes Carvalho; Flavia Gonçalves; Hector Valentin Caballero-Flores; Ana Clara Fagundes Pedroni; Cesar Angelo Lascala; Luiz Henrique Catalani; Márcia Martins Marques

Publisher

Hindawi Limited

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)