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Sonodynamic excitation of nanomicelle curcumin for eradication of Streptococcus mutans under sonodynamic antimicrobial chemotherapy: Enhanced anti-caries activity of nanomicelle curcumin by Maryam Pourhajibagher; Bahman Rahimi esboei; Mahshid Hodjat; Abbas Bahador is a Medicine article available to read on EtoBox.

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## Background: Inactivation of microorganisms related to dental caries has been considered the therapy of choice in the treatment of caries. the proposed study aims to assess the effect of sonodynamic excitation of nanomicelle curcumin (nm@cur) compared to cur for eradication of streptococcus mutans under sonodynamic antimicrobial chemotherapy (sact). ## Materials and methods: The nm@cur as a sonosensitizer was synthesized and its morphology, particle size distribution, zeta potential, and physical stability were then determined. after evaluating the cur and nm@cur uptake in s. mutans strain, cur- and nm@cur-sact effects were determined on colony forming unit (cfu/ml) and reactive oxygen species (ros) levels. additionally, cytotoxicity and apoptotic effects of cur- and nm@cur-sact on human gingival fibroblast (hgf) cells were assessed using mtt assay and flow cytometry analysis, respectively. ## Results: Transmission electron microscope, particle size distribution, and zeta potential analysis confirmed successful synthesis of nm@cur. the finding of this study showed that an incubation time of 5 min to 1 h was sufficient to achieve maximal uptake of cur and nm@cur in s. mutans. sact

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Author

Maryam Pourhajibagher; Bahman Rahimi esboei; Mahshid Hodjat; Abbas Bahador

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1572-1000)

Published

2020

Language

EN

Field

Medicine (Health Sciences)