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Increased Expression of the Matrix Metalloproteinase 2 in Differentiating Tera 2 Human Embryonal Carcinoma Cells by Jukka Tienari; Liisa Pertovaara; Olli Saksela; Eero Lehtonen; Tapio Vartio is a Medicine article available to read on EtoBox.

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## Secretion of proteolytic enzymes by cells has been implicated in tissue remodeling during embryonic development as well as in invasive neoplastic diseases. We studied the regulation of type-IV-collagenase activity in Tera 2 human embryonal carcinoma cells, which in the undifferentiated state proliferate rapidly and are tumorigenic. The undifferentiated cells produced relatively low levels of matrix-metalloproteinase-2 (MMP-2) activity. This activity was not markedly affected by exogenous basic fibroblast growth factor (bFGF) or I2-0tetradecanoyl-phorbol-13-acetate (TPA), even though the plasminogen activator activity of the cells was increased by these agents. Tera 2 cells can be induced by retinoic acid to differentiate into quiescent cells, of which many express neuronal characteristics. The type-IV-collagenase activity of the cells increased markedly during the differentiation. This increase was mainly due to increased expression of MMP-2. Expression of tissue inhibitors of metalloproteinases (TIMP-I and TIMP-2) was not markedly affected by the differentiation of Tera 2 cells. The results show that in the Tera 2 cell system, increased expression of MMP-2 is characteristic of

Who reads Increased Expression of the Matrix Metalloproteinase 2 in Differentiating Tera 2 Human Embryonal Carcinoma Cells?

Author

Jukka Tienari; Liisa Pertovaara; Olli Saksela; Eero Lehtonen; Tapio Vartio

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1994

Language

EN

Field

Medicine (Health Sciences)