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Can I read A New Supercritical Co-injection Process to Coat Microparticles on EtoBox?
A New Supercritical Co-injection Process to Coat Microparticles by Marilyn Calderone; Elisabeth Rodier; Hubert Lochard; Florence Marciacq; Jacques Fages is a Engineering article available to read on EtoBox.
What is A New Supercritical Co-injection Process to Coat Microparticles about?
A new supercritical co-injection process has been developed to coat microparticles. The process was first set up with micron-sized glass beads as model particles and then applied to two powdered active pharmaceutical ingredients. A lipid was used as coating material. The mass balance core/shell in the obtained particles was performed using both differential scanning calorimetry (DSC) and pycnometry measurements and showed a good reproducibility of the process when particles above 20 m size were considered. Fourier transform infrared (FT-IR) spectra and environmental scanning electronic microscope (ESEM) characterization were used to ensure that a shell of coating surrounded the raw particles. Both methods showed a different deposition mode of the lipid between the coated particles and a physical mixture of glass beads and lipid. Release tests in distilled water performed with coated active compounds showed a slowed down dissolution kinetics. The study of the polymorphism of the crystallized lipid revealed a solid/solid transition with time. The supercritical co-injection process is a promising way to discretely coat particles with relatively low diameters (20-50 m) and is particula
Who reads A New Supercritical Co-injection Process to Coat Microparticles?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Marilyn Calderone; Elisabeth Rodier; Hubert Lochard; Florence Marciacq; Jacques Fages
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0255-2701)
- Published
- 2008
- Language
- EN
- Field
- Engineering (Physical Sciences)