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Analogues Of Nucleic Acid Components: Mechanisms Of Action (recent Results In Cancer Research) by P. Roy-Burman Ph. D. (auth.), P. Roy-Burman Ph. D. (eds.) is a nonfiction available to read on EtoBox.

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The rationale for the design of structural analogues of a normal metabolite is that such compounds may interfere in the utilization or function of the metabolite. A compound which is effective in this respect may be called an antimetabolite. To be successful in chemotherapy of bacterial, viral, or tumor growth, an antimetabolite should adversely affect some vital metabolic reactions in the parasite or parasitic tissue without seriously endangering the host tissue. If a metabolic process of the offending growth is different from that of the host, it is likely that the metabolism or activity of a compound, structurally related to a metabolite involved in that process, will also be different in these cells. Such differences are useful for devising effective drugs with selective actions. Sulfanilamide, a structural analogue of para aminobenzoic acid, interferes with the utilization of this metabolite in the synthesis of folic acid, an essential factor for growth. Bacteria synthesize their own folic acid and are incapable of utilizing exogenously available folic acid. However, the situation is exactly opposite in the animal host. That is, animal tissues cannot synthesize folic acid and

Who reads Analogues Of Nucleic Acid Components: Mechanisms Of Action (recent Results In Cancer Research)?

Author

P. Roy-Burman Ph. D. (auth.), P. Roy-Burman Ph. D. (eds.)

Publisher

Springer-Verlag Berlin Heidelberg

Published

1970

Language

EN

ISBN

9783642855764

Category

nonfiction

Subjects

Science, Medical, Medicine