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The role of STAT6 in mast cell IL-4 production by Melanie A. Sherman is a Immunology and Microbiology article available to read on EtoBox.

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**Summary:** Interleukin (IL)‐4 has an important role in regulating antibody production and inflammation. The major IL‐4 producers are CD4^+^ T cells, but the development of an IL‐4‐producing phenotype in these cells requires IL‐4 signaling through the STAT6 pathway during differentiation. The cellular source of this early IL‐4 is not known, but mast cells are a possible candidate due to their immediate and indiscriminate release of IL‐4 upon activation. In this review we summarize the evidence that STAT6 signaling is not required for mast cell IL‐4 production, which is consistent with their possible role as a link between the innate immune response and T‐cell activation. We also describe an isoform of STAT6 that is expressed in mast cells and that appears to act as a repressor of IL‐4 transcription. This STAT6 signaling pathway may be part of a feedback mechanism to protect surrounding tissues from IL‐4‐mediated inflammation during an infection. The author would like to thank Dr. Melissa Brown for her generous support, helpful discussions and critical review of the manuscript and Dr. Virginia Secor for her collaboration with this project. Drs. Andrew Neish, Jeremy Boss and S. Wrig

Who reads The role of STAT6 in mast cell IL-4 production?

Author

Melanie A. Sherman

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0105-2896)

Published

2001

Language

EN

Field

Immunology and Microbiology (Life Sciences)