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Within-subregion Relationship Between Bone Marrow Lesions and Subsequent Cartilage Loss in Knee Osteoarthritis by Ami Kothari; Ali Guermazi; Joan S. Chmiel; Dorothy Dunlop; Jing Song; Orit Almagor; Meredith Marshall; September Cahue; Pottumarthi Prasad; Leena Sharma is a Medicine article available to read on EtoBox.

What is Within-subregion Relationship Between Bone Marrow Lesions and Subsequent Cartilage Loss in Knee Osteoarthritis about?

## Abstract ## Objective Bone marrow lesions are believed to increase risk of knee osteoarthritis (OA) progression. Whether their effect is local and whether it can be explained by other types of bone lesions concomitantly present in the same subregion is unclear. We evaluated bone lesion frequency in subregions without cartilage lesions and cartilage lesion frequency in subregions without bone lesions, and investigated the within‐subregion bone marrow lesion/subsequent cartilage loss relationship after adjusting for other types of bone lesions at baseline. ## Methods Individuals with knee OA had magnetic resonance imaging at baseline and 2 years later. Cartilage integrity and bone marrow lesions, cysts, and attrition were scored within tibiofemoral subregions. Logistic regression, with generalized estimating equations to account for correlation among multiple subregions within a knee, was used to estimate odds ratios (ORs) for cartilage loss associated with bone marrow lesions, adjusting for age, sex, body mass index, and bone attrition and cysts in the same subregion. ## Results Analyzing 1,953 subregions among 177 knees, 90% of subregions had no bone lesions at baseline. Only 0–

Who reads Within-subregion Relationship Between Bone Marrow Lesions and Subsequent Cartilage Loss in Knee Osteoarthritis?

Author

Ami Kothari; Ali Guermazi; Joan S. Chmiel; Dorothy Dunlop; Jing Song; Orit Almagor; Meredith Marshall; September Cahue; Pottumarthi Prasad; Leena Sharma

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 2151-464X)

Published

2010

Language

EN

Field

Medicine (Health Sciences)