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Spatiotemporal analysis of NO production upon NMDA and tetanic stimulation of the hippocampus by Norio Takata; Tokiko Harada; John A. Rose; Suguru Kawato is a Neuroscience article available to read on EtoBox.

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## Abstract Nitric oxide (NO) is a gaseous neuromessenger. Although increasing evidence reveals significant physiological effects of NO in the hippocampal synaptic plasticity, the spatial distribution of NO production has remained largely uncharacterized due to the poor development of techniques for real‐time NO imaging. In this work, using a NO‐reactive fluorescent dye, diaminorhodamine‐4M (DAR‐4M), time‐dependent heterogeneous NO production is demonstrated in hippocampal slices upon N‐methyl‐D‐aspartate (NMDA) stimulation or tetanic stimulation. NMDA‐induced DAR fluorescence increase in the CA1 was found to be twice that in the CA3 and the dentate gyrus (DG). Intracellular Ca^2+^ concentration was also investigated. NMDA induced similar Ca^2+^ responses both in the CA1 and DG, which were approx. 13% greater than that in the CA3. Subsequently, spatial distribution of NO production in the CA1 upon a tetanic stimulation of Schaffer collateral was investigated, because there are contradictory reports on the effect of NO on long‐term potentiation (LTP), and that NO is known to exert various physiological effects depending on its concentration. In the stratum radiatum (sr), DAR fluores

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Author

Norio Takata; Tokiko Harada; John A. Rose; Suguru Kawato

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1050-9631)

Published

2005

Language

EN

Field

Neuroscience (Life Sciences)