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Impact of Helicobacter pylori infection status on outcomes among patients with advanced gastric cancer treated with immune checkpoint inhibitors by Patrick T Magahis; Steven B Maron; Darren Cowzer; Stephanie King; Mark Schattner; Yelena Janjigian; David Faleck; Monika Laszkowska is a Medicine article available to read on EtoBox.
What is Impact of Helicobacter pylori infection status on outcomes among patients with advanced gastric cancer treated with immune checkpoint inhibitors about?
## Background Gut microbiota composition can influence cancer immunotherapy response. Recent evidence suggests__Helicobacter pylori__infection may reduce immune checkpoint inhibitor (ICI) efficacy in lung cancer and melanoma, but thorough characterization of this association in patients with gastric cancer is lacking. We aimed to determine the impact of__H. pylori__on survival in this population. ## Methods This single-center, retrospective study included all ICI-treated individuals with metastatic gastric cancer and documented__H. pylori__status at Memorial Sloan Kettering between July 2013 and October 2021.__H. pylori__-positive status was defined as history of infection obtained via breath test, stool antigen test, histopathology, and/or chart documentation. Negative status was defined as explicitly negative testing, histopathology, and/or chart documentation. Primary outcomes were progression-free survival (PFS) and overall survival (OS). ## Results Of 215 included patients, 49 had documented history of__H. pylori__infection. Compared with__H. pylori-__negative patients, positive individuals tended to be younger, non-white, and Hispanic with non-cardia and intestinal-type gastr
Who reads Impact of Helicobacter pylori infection status on outcomes among patients with advanced gastric cancer treated with immune checkpoint inhibitors?
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- Author
- Patrick T Magahis; Steven B Maron; Darren Cowzer; Stephanie King; Mark Schattner; Yelena Janjigian; David Faleck; Monika Laszkowska
- Publisher
- BMJ
- Published
- 2023
- Field
- Medicine (Health Sciences)