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Oxidized Phosphatidylcholines Found in Multiple Sclerosis Lesions Mediate Neurodegeneration and Are Neutralized by Microglia by Yifei Dong; Charlotte D’Mello; William Pinsky; Brian M. Lozinski; Deepak K. Kaushik; Samira Ghorbani; Dorsa Moezzi; Dennis Brown; Francisca C. Melo; Stephanie Zandee; Tina Vo; Alexandre Prat; Shawn N. Whitehead; V. Wee Yong is a Neuroscience article available to read on EtoBox.

What is Oxidized Phosphatidylcholines Found in Multiple Sclerosis Lesions Mediate Neurodegeneration and Are Neutralized by Microglia about?

S is a neurodegenerative disease in which demyelination and axon loss in the CNS lead to lifelong disabilities. Active lesions in patients with MS have an accumulation of immune cells that produce proinflammatory cytokines and free radicals that contribute to the pathology 1,2 . In the healthy CNS, lipid-rich myelin ensheath axons to aid electrical impulse conduction and provide metabolic support. In MS, myelin debris in lesions require clearance by phagocytes such as microglia 3 . As free radicals can oxidize myelin in vitro 4 , the myelin debris in MS lesions may undergo peroxidation and generate oxidized phosphatidylcholines (OxPCs). In non-CNS conditions such as non-alcoholic steatohepatitis, atherosclerosis and lung injury, OxPCs promote cell death and exacerbate inflammation and injury . While OxPCs and OxPC-reactive antibodies are found in the brain and cerebrospinal fluid, respectively, of patients with MS , OxPC formation in MS is viewed as a marker of oxidative stress. Whether OxPCs are toxic in MS is unclear.Microglia are embryonically derived resident macrophages of the CNS parenchyma. In homeostasis, they have important functions such as pruning synapses, aiding myelin

Who reads Oxidized Phosphatidylcholines Found in Multiple Sclerosis Lesions Mediate Neurodegeneration and Are Neutralized by Microglia?

Author

Yifei Dong; Charlotte D’Mello; William Pinsky; Brian M. Lozinski; Deepak K. Kaushik; Samira Ghorbani; Dorsa Moezzi; Dennis Brown; Francisca C. Melo; Stephanie Zandee; Tina Vo; Alexandre Prat; Shawn N. Whitehead; V. Wee Yong

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Neuroscience (Life Sciences)