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PGE2 displays immunosuppressive effects during human active tuberculosis by Pellegrini, Joaquín Miguel (author);Martin, Candela (author);Morelli, María Paula (author);Schander, Julieta Aylen (author);Tateosian, Nancy Liliana (author);Amiano, Nicolás Oscar (author);Rolandelli, Agustín (author);Palmero, Domingo Juan (author);Levi, Alberto (author);Ciallella, Lorena (author);Colombo, María Isabel (author);García, Verónica Edith (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is PGE2 displays immunosuppressive effects during human active tuberculosis about?

Prostaglandin E2 (PGE2), an active lipid compound derived from arachidonic acid, regulates different stages of the immune response of the host during several pathologies such as chronic infections or cancer. In fact, manipulation of PGE2 levels was proposed as an approach for countering the Type I IFN signature of tuberculosis (TB). However, very limited information regarding the PGE2 pathway in patients with active TB is currently available. In the present work, we demonstrated that PGE2 exerts a potent immunosuppressive action during the immune response of the human host against __Mycobacterium tuberculosis (Mtb)__ infection. Actually, we showed that PGE2 significantly reduced the surface expression of several immunological receptors, the lymphoproliferation and the production of proinflammatory cytokines. In addition, PGE2 promoted autophagy in monocytes and neutrophils cultured with __Mtb__ antigens. These results suggest that PGE2 might be attenuating the excessive inflammatory immune response caused by __Mtb__, emerging as an attractive therapeutic target. Taken together, our findings contribute to the knowledge of the role of PGE2 in the human host resistance to __Mtb__ and

Who reads PGE2 displays immunosuppressive effects during human active tuberculosis?

It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.

Author
Pellegrini, Joaquín Miguel (author);Martin, Candela (author);Morelli, María Paula (author);Schander, Julieta Aylen (author);Tateosian, Nancy Liliana (author);Amiano, Nicolás Oscar (author);Rolandelli, Agustín (author);Palmero, Domingo Juan (author);Levi, Alberto (author);Ciallella, Lorena (author);Colombo, María Isabel (author);García, Verónica Edith (author)
Publisher
Springer Science and Business Media LLC
Published
2021
Language
EN
Field
Biochemistry, Genetics and Molecular Biology (Life Sciences)

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