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Association of Tumor Necrosis Factor α Polymorphism, but Not the Shared Epitope, with Increased Radiographic Progression in a Seropositive Rheumatoid Arthritis Inception Cohort by Dinesh Khanna; Hui Wu; Grace Park; Vivian Gersuk; Richard H. Gold; Gerald T. Nepom; Weng Kee Wong; John T. Sharp; Elaine F. Reed; Harold E. Paulus; Betty P. Tsao; Western Consortium of Practicing Rheumatologists is a Medicine article available to read on EtoBox.

What is Association of Tumor Necrosis Factor α Polymorphism, but Not the Shared Epitope, with Increased Radiographic Progression in a Seropositive Rheumatoid Arthritis Inception Cohort about?

## Abstract ## Objective To determine whether the tumor necrosis factor α (__TNFA__) –308 guanine‐to‐adenosine polymorphism and/or the shared epitope (SE) is associated with radiographic damage in patients with early rheumatoid arthritis (RA). ## Methods The cohort consisted of 189 patients with early seropositive RA (median 5.6 months since symptom onset) who had active disease, no previous disease‐modifying antirheumatic drug treatment, and ≥2 sets of scored radiographs of the hands/wrists and forefeet. __TNFA__ –308 polymorphism was analyzed by polymerase chain reaction pyrosequencing. The SE was defined as presence of any 1 of the following HLA–DRB1 alleles: \*0101, \*0102, \*0401, \*0404, \*0405, \*0408, \*0410, \*1001, \*1402, or \*1406. Radiographic progression was assessed by the total Sharp score. ## Results Using a weighted least‐squares regression analysis, patients with the –308 __TNFA__ AA plus AG genotypes (n = 49) had significantly higher rates of progression in erosion scores (median 0.84 versus 0.48 units/year), joint space narrowing (JSN) scores (0.42 versus 0.04), and total Sharp scores (1.70 versus 0.61) compared with patients with the __TNFA__ GG genotype (n =

Who reads Association of Tumor Necrosis Factor α Polymorphism, but Not the Shared Epitope, with Increased Radiographic Progression in a Seropositive Rheumatoid Arthritis Inception Cohort?

Author

Dinesh Khanna; Hui Wu; Grace Park; Vivian Gersuk; Richard H. Gold; Gerald T. Nepom; Weng Kee Wong; John T. Sharp; Elaine F. Reed; Harold E. Paulus; Betty P. Tsao; Western Consortium of Practicing Rheumatologists

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)

Published

2006

Language

EN

Field

Medicine (Health Sciences)