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Urinary Symptom Flare in 712 125I Prostate Brachytherapy Patients: Long-Term Follow-Up by Mira Keyes; Stacy Miller; Veronika Moravan; Tom Pickles; Mitchell Liu; Ingrid Spadinger; Vincent Lapointe; W. James Morris is a Medicine article available to read on EtoBox.

What is Urinary Symptom Flare in 712 125I Prostate Brachytherapy Patients: Long-Term Follow-Up about?

Purpose: To describe the late transient worsening of urinary symptoms (''urinary symptom flare'') in 712 consecutive prostate brachytherapy patients, associated predictive factors, association with rectal and urinary toxicity, and the development of erectile dysfunction. Methods and Materials: Patients underwent implantation between 1998 and 2003 (median follow-up, 57 months). International Prostate Symptom Score (IPSS), Radiation Therapy Oncology Group (RTOG) toxicity, and erectile function data were prospectively collected. Flare was defined as an increase in IPSS of $5 and of $8 points greater than the post-treatment nadir. The relationships between the occurrence of flare and the patient, tumor, and treatment characteristics were examined. The Cox proportional hazards method was used to test individual variables and the multivariate models. Results: The incidence of flare was 52% and 30% using the flare definition of an IPSS of $5 and $8 points greater than the postimplant nadir, respectively. Of the patients with symptoms, 65% had resolution of their symptoms within 6 months and 91% within 1 year. Flares most commonly occurred 16-24 months after implantation. On multivariate a

Who reads Urinary Symptom Flare in 712 125I Prostate Brachytherapy Patients: Long-Term Follow-Up?

Author

Mira Keyes; Stacy Miller; Veronika Moravan; Tom Pickles; Mitchell Liu; Ingrid Spadinger; Vincent Lapointe; W. James Morris

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2009

Language

EN

Field

Medicine (Health Sciences)