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Incorporation of Vasculature in a Head Injury Model Lowers Local Mechanical Strains in Dynamic Impact by Zhao, Wei; Ji, Songbai is a Medicine article available to read on EtoBox.

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Cerebral vasculature is several orders of magnitude stiffer than the brain tissue. However, only a handful of studies have investigated its potential stiffening effect on dynamic brain strains; yet, they report contradictory findings. Here, we reanalyze the cerebrovascular stiffening effect by incorporating vasculature derived from the latest neuroimaging atlases into a re-meshed Worcester Head Injury Model using an embedded element method. Regional brain strains with and without vasculature were simulated using a reconstructed, predominantly sagittal head impact. Using the two previously adopted linear or non-linear vessel material models, we reproduced the earlier conflicting results (~40% vs. ~1-6% in regional strain reductions). Nevertheless, with refitted non-linear material models chosen to represent the average dynamic tension behaviors of arteries and veins, respectively, inclusion of vasculature reduced regional brain strains by ~13-36% relative to the baselines without vasculature. Compared to the whole brain baseline response, inclusion of vasculature led to an element-wise linear regression slope of 0.8 and a Pearson correlation coefficient of 0.8. The vascular stiffeni

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Author

Zhao, Wei; Ji, Songbai

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0021-9290)

Published

2020

Language

EN

Field

Medicine (Health Sciences)