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Impaired sense of smell and color discrimination in monogenic and idiopathic Parkinson's disease by Lena Kertelge; Norbert Brüggemann; Alexander Schmidt; Vera Tadic; Claudia Wisse; Sylwia Dankert; Laura Drude; Joyce van der Vegt; Hartwig Siebner; Heike Pawlack; Peter P. Pramstaller; Maria Isabel Behrens; Alfredo Ramirez; Dirk Reichel; Carsten Buhmann; Johann Hagenah; Christine Klein; Katja Lohmann; Meike Kasten is a Medicine article available to read on EtoBox.
What is Impaired sense of smell and color discrimination in monogenic and idiopathic Parkinson's disease about?
## Abstract Olfaction is typically impaired in idiopathic Parkinson's disease (IPD), but its role is uncertain in monogenic PD. Diminished color discrimination has been suggested as another early sign of dopaminergic dysfunction but not been systematically studied. Furthermore, it is unknown whether both deficits are linked. We examined 100 patients with IPD, 27 manifesting mutation carriers (MC), 20 nonmanifesting mutation carriers (NMC), and 110 controls. Participants underwent a standardized neurological examination, the University of Pennsylvania Smell Identification Test (UPSIT), the Farnsworth‐Munsell (FM) color discrimination test, and mutation testing in known PD genes. The monogenic group consisted of 15 __Parkin__ (6MC/9NMC), 17 __PINK1__ (10MC/7NMC), 8 __LRRK2__ (4MC/4NMC), 3 __SNCA__ (MC), and 4 __ATP13A2__ (MC) carriers. Olfaction was most impaired in IPD (UPSIT percentiles 10.1 ± 13.5) compared with all other groups (MC 13.8 ± 11.9, NMC 19.6 ± 13.0, controls 33.8 ± 22.4). Within MC, carriers of two mutations in __Parkin__ and __PINK1__ showed higher UPSIT percentiles than __LRRK2__ and __SNCA__ carriers. Color discrimination was reduced in IPD (FM total error score 13
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- Author
- Lena Kertelge; Norbert Brüggemann; Alexander Schmidt; Vera Tadic; Claudia Wisse; Sylwia Dankert; Laura Drude; Joyce van der Vegt; Hartwig Siebner; Heike Pawlack; Peter P. Pramstaller; Maria Isabel Behrens; Alfredo Ramirez; Dirk Reichel; Carsten Buhmann; Johann Hagenah; Christine Klein; Katja Lohmann; Meike Kasten
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)