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Diagnosis of perinatal stroke II: mechanisms and clinical phenotypes by P Govaert; L Ramenghi; R Taal; J Dudink; M Lequin is a Medicine article available to read on EtoBox.

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## Abstract **Introduction:** Here (and in an accompanying article dealing with definitions, differential diagnosis and registration), a structured sequential diagnostic flow is proposed to discern clinical phenotypes for perinatal stroke, including arterial ischaemic stroke (AIS), cerebral sinovenous thrombosis (CSVT) and haemorrhagic stroke. **Material and results:** For neonatal AIS, the diagnostic sequence is infection, trauma, embolism, arteriopathy, other, primary thrombosis and unclassifiable; for neonatal CSVT, the sequence is infection, trauma, venopathy, other, primary thrombosis and unclassifiable. The proposed hierarchical diagnostic flows are an initial step towards a standard for registration of the causes of neonatal stroke. Such standardization should guide attempts at prevention and intervention. An extensive literature search and study of a retrospective cohort of 134 newborn infants with stroke suggest that embolism is the most common identifiable cause for stroke in general (25%), preceding trauma (10%) and infection (8%). Other causes, such as asphyxia, acute blood loss, extracorporeal membrane oxygenation, genetic disorders or prothrombotic conditions, are see

Who reads Diagnosis of perinatal stroke II: mechanisms and clinical phenotypes?

Author

P Govaert; L Ramenghi; R Taal; J Dudink; M Lequin

Publisher

Wiley

Published

2009

Language

EN

Field

Medicine (Health Sciences)