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Preserving Fertility in Young Patients with Endometrial Cancer: Current Perspectives by Jamie Bakkum-Gamez; Eleftheria Kalogera; Sean Dowdy is a Medicine article available to read on EtoBox.

What is Preserving Fertility in Young Patients with Endometrial Cancer: Current Perspectives about?

Endometrial cancer (EC) is the most common gynecologic malignancy in developed countries and affects predominantly postmenopausal women. It is estimated, however, that 15%–25% of women will be diagnosed before menopause. As more women choose to defer childbearing until later in life, the feasibility and safety of fertility-sparing EC management have been increasingly studied. Definitive treatment of total hysterectomy and bilateral salpingo-oophorectomy precludes future fertility and may thus be undesirable by women who wish to maintain their reproductive potential. However, the consideration of conservative management carries the oncologic risks of unstaged EC and the risk of missing a synchronous ovarian cancer. It is further complicated by the lack of consensus regarding the initial assessment, treatment, and surveillance. Conservative treatment with progestins has been shown to be a feasible and safe fertility-sparing approach for women with low grade, early stage EC with no myometrial invasion. The two most commonly adopted regimens are medroxyprogesterone acetate at 500–600 mg daily and megestrol acetate at 160 mg daily for a minimum of 6–9 months, with initial response rates

Who reads Preserving Fertility in Young Patients with Endometrial Cancer: Current Perspectives?

Author

Jamie Bakkum-Gamez; Eleftheria Kalogera; Sean Dowdy

Publisher

Informa UK Limited

Published

2014

Language

EN

Field

Medicine (Health Sciences)