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Can I read VEGF-Modified PVA/Silicone Nanofibers Enhance Islet Function Transplanted in Subcutaneous Site Followed by Device-Less Procedure on EtoBox?
VEGF-Modified PVA/Silicone Nanofibers Enhance Islet Function Transplanted in Subcutaneous Site Followed by Device-Less Procedure by Yang, Bin; Cao, Guodong; Cai, Kailun; Wang, Gang; Li, Pengping; Zheng, Lei; Cai, Haolei; Zhu, Yi; Li, Xiang; Wu, Yulian is a Materials Science article available to read on EtoBox.
What is VEGF-Modified PVA/Silicone Nanofibers Enhance Islet Function Transplanted in Subcutaneous Site Followed by Device-Less Procedure about?
## Introduction As heterologous islets or islet-like stem cells become optional sources for islet transplantation, the subcutaneous site appears to be an acceptable replacement of the intrahepatic site due to its graft retrievability. The device-less (DL) procedure improves the feasibility; however, some limitations such as fibrotic overgrowth or immunodeficiency still exist. Nanofibers could mimic the extracellular matrix to improve the vitality of transplanted islets. Therefore, we designed a vascular endothelial growth factor (VEGF)-modified polyvinyl alcohol (PVA)/silicone nanofiber (SiO2-VEGF) to optimize the DL procedure. ## Methods SiO2-VEGF nanofibers were designed by nano-spinning and characterized the physical-chemical properties before subcutaneous islet transplantation. Cell viability, vessel formation, and glucose-stimulated insulin secretion were tested in vitro to ensure biocompatibility; and blood glucose level (BGL), transplanted islet function, and epithelial–mesenchymal transition (EMT)-related biomarker expression were analyzed in vivo. ## Results The intensity of inflammatory reaction induced by SiO2 nanofibers was between nylon and silicone, which did not brin
Who reads VEGF-Modified PVA/Silicone Nanofibers Enhance Islet Function Transplanted in Subcutaneous Site Followed by Device-Less Procedure?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Yang, Bin; Cao, Guodong; Cai, Kailun; Wang, Gang; Li, Pengping; Zheng, Lei; Cai, Haolei; Zhu, Yi; Li, Xiang; Wu, Yulian
- Publisher
- Dove Press Ltd.; Dove Medical Press; Dove Medical Press Ltd; [Auckland N.Z.]: Dovepress; Informa UK Limited (ISSN 1176-9114)
- Published
- 2020
- Language
- EN
- Field
- Materials Science (Physical Sciences)