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Adeno-associated Virus Vector-mediated Gene Therapy for the Treatment of Ovarian Cancer: a Literature Review by Jiaojiao Zhu; Tiansheng Qin; Linzhen Wei; Fan Chen; Yaoyao Ding; Qianqian Zhang; Yamei Dang is a Medicine article available to read on EtoBox.

What is Adeno-associated Virus Vector-mediated Gene Therapy for the Treatment of Ovarian Cancer: a Literature Review about?

## Background and Objective The adeno-associated virus (AAV) is a member of the Parvoviridae family and has emerged as one of the most popular and promising approaches for gene therapy due to its low toxicity, low immunogenicity, and excellent safety after optimization. Advances in gene therapy methods have allowed novel treatments such as using AAV to knock out or repair target genes. AAV-mediated gene therapy has been used in numerous tumor studies, including lymphatic metastasis of prostate cancer, liver cancer, and renal cell carcinoma in mice. Ovarian cancer is an extremely aggressive malignancy which is prone to recurrence, and AAV vector-based gene therapy may be a potential treatment strategy. ## Methods Herein, we reviewed the current research to provide an update on the role of AAV-mediated gene therapy in tumor research, especially in ovarian cancer. To find recent developments in pertinent research, we examined the PubMed database. ## Key Content and Findings AAV vectors may produce steady and effective gene expression without becoming harmful, making it a viable gene delivery technique. AAV-based gene therapy products have been widely used in preclinical research and s

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Author

Jiaojiao Zhu; Tiansheng Qin; Linzhen Wei; Fan Chen; Yaoyao Ding; Qianqian Zhang; Yamei Dang

Published

2022

Language

EN

Field

Medicine (Health Sciences)