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Can I read Cervical Spinal Cord Injury-induced Neuropathic Pain in Male Mice Is Associated with a Persistent Pro-inflammatory Macrophage/microglial Response in the Superficial Dorsal Horn on EtoBox?
Cervical Spinal Cord Injury-induced Neuropathic Pain in Male Mice Is Associated with a Persistent Pro-inflammatory Macrophage/microglial Response in the Superficial Dorsal Horn by Eric V. Brown; Aditi Falnikar; Nicolette Heinsinger; Lan Cheng; Carrie E. Andrews; Michael DeMarco; Angelo C. Lepore is a Neuroscience article available to read on EtoBox.
What is Cervical Spinal Cord Injury-induced Neuropathic Pain in Male Mice Is Associated with a Persistent Pro-inflammatory Macrophage/microglial Response in the Superficial Dorsal Horn about?
A significant portion of individuals living with traumatic spinal cord injury (SCI) experiences some degree of debilitating neuropathic pain (NP). This pain remains largely intractable in a majority of cases, due in part to an incomplete understanding of its underlying mechanisms. Central sensitization, an increase in excitability of pain transmission neurons located in superficial dorsal horn (sDH), plays a key role in development and maintenance of SCI-induced NP. Resident microglia and peripheral monocyte-derived macrophages (referred to collectively as MMΦ) are involved in promoting SCI-induced DH neuron hyperexcitability. Importantly, these MMΦ consist of populations of cells that can exert pro-inflammatory or anti-inflammatory signaling within injured spinal cord. It is critical to spatiotemporally characterize this heterogeneity to understand MMΦ contribution to NP after SCI. Given that a majority of SCI cases are cervical in nature, we used a model of unilateral C5/C6 contusion that results in persistent at-level thermal hyperalgesia and mechanical allodynia, two forms of NP-related behavior, in the forepaw. The aim of this study was to characterize the sDH MMΦ response wit
Who reads Cervical Spinal Cord Injury-induced Neuropathic Pain in Male Mice Is Associated with a Persistent Pro-inflammatory Macrophage/microglial Response in the Superficial Dorsal Horn?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Eric V. Brown; Aditi Falnikar; Nicolette Heinsinger; Lan Cheng; Carrie E. Andrews; Michael DeMarco; Angelo C. Lepore
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Neuroscience (Life Sciences)