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Can I read Val-Tyr As A Natural Antihypertensive Dipeptide Can Be Absorbed Into The Human Circulatory Blood System on EtoBox?
Val-Tyr As A Natural Antihypertensive Dipeptide Can Be Absorbed Into The Human Circulatory Blood System by Toshiro Matsui; Kei Tamaya; Eiji Seki; Katsuhiro Osajima; Kiyoshi Matsumoto; Terukazu Kawasaki is a Medicine article available to read on EtoBox.
What is Val-Tyr As A Natural Antihypertensive Dipeptide Can Be Absorbed Into The Human Circulatory Blood System about?
## SUMMARY 1. Intact absorption of the bioactive dipeptide Val‐Tyr (VY), with __in vivo__ antihypertensive ability in normotensive human subjects, was investigated. 2. As a result of a single oral administration of VY, the VY absorption curve occurred maximally over the second hour postprandially; a greater than 10‐fold higher increment of VY following a dose of 12 mg was observed in the plasma at 2 h compared with the baseline concentration of VY at 0 h (1934 **±** 145 __vs__ 159 **±** 11 fmol/mL plasma, respectively). 3. Plasma VY levels increased with dose administered (3, 6 and 12 mg), suggesting that exogenous VY could be absorbed intact into the human blood depending on the dose. The elimination half time (t^1^/~2~) of VY was estimated to be 3.1 h. The area under the curve for the 12 mg VY dose was 9185 **±** 688 fmol·h/mL plasma.
Who reads Val-Tyr As A Natural Antihypertensive Dipeptide Can Be Absorbed Into The Human Circulatory Blood System?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Toshiro Matsui; Kei Tamaya; Eiji Seki; Katsuhiro Osajima; Kiyoshi Matsumoto; Terukazu Kawasaki
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0305-1870)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)