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1) Propolis was found to suppress tumor-induced angiogenesis both in vivo in a mouse model and in vitro by inhibiting tube formation of endothelial cells. 2) In the mouse model, oral administration of 5% propolis significantly reduced the formation of new blood vessels compared to controls. 3) In vitro, propolis inhibited tube formation of human endothelial cells and induced apoptosis in these cells, suggesting propolis exerts its anti-angiogenic effects through inducing apoptosis in endothelial cells.

Author

MirelaMilan

Language

EN