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Can I read Peripherally injected canabidiol reduces neuropathic pain in mice: Role of the 5-HT1A and TRPV1 receptors on EtoBox?
Peripherally injected canabidiol reduces neuropathic pain in mice: Role of the 5-HT1A and TRPV1 receptors by Danielle Diniz Aguiar; Cristina da Costa Oliveira; Flávia Cristina Sousa Fonseca; Douglas Lamounier de Almeida; William Valadares Campos Pereira; Francisco Silveira Guimarães; Andrea Castro Perez; Igor Dimitri Gama Duarte; Thiago Roberto Lima Romero is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Peripherally injected canabidiol reduces neuropathic pain in mice: Role of the 5-HT1A and TRPV1 receptors about?
Cannabidiol (CBD) is the most abundant non-psychoactive component found in plants of the genus Cannabis. Its analgesic effect for the treatment of neuropathy has been widely studied. However, little is known about its effects in the acute treatment when Cannabidiol is administered peripherally. Because of that, this research was aimed to evaluate the antinociceptive effects of the CBD when administered peripherally for the treatment of acute neuropathic pain and check the involvement of the 5-HT1A and the TRPV1 receptors in this event. Neuropathic pain was induced with the constriction of the sciatic nerve while the nociceptive threshold was measured using the pressure test of the mouse paw. The technique used proved to be efficient to induce neuropathy, and the CBD (5, 10 and 30 μg/paw) induced the antinociception in a dosage-dependent manner. The dosage used that induced a more potent effect (30 μg/paw), did not induce a systemic response, as demonstrated by both the motor coordination assessment test (RotaRod) and the antinociceptive effect restricted to the paw treated with CBD. The administration of NAN-190 (10 μg/paw), a selective 5-HT1A receptor antagonist, and SB-366791 (16
Who reads Peripherally injected canabidiol reduces neuropathic pain in mice: Role of the 5-HT1A and TRPV1 receptors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Danielle Diniz Aguiar; Cristina da Costa Oliveira; Flávia Cristina Sousa Fonseca; Douglas Lamounier de Almeida; William Valadares Campos Pereira; Francisco Silveira Guimarães; Andrea Castro Perez; Igor Dimitri Gama Duarte; Thiago Roberto Lima Romero
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)