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Synthesis of Functionally Diverse Bicyclic Sulfonamides as Constrained Proline Analogues and Application to the Design of Potential Thrombin Inhibitors by Stephen Hanessian; Helen Sailes; Eric Therrien is a Chemistry article available to read on EtoBox.

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Bicyclic sulfonamides were synthesized from 4-alkenyl N-alkenylsulfonyl L-prolines using a ring-closure metathesis reaction. Three types of bicyclic sulfonamides varying in the size of the second ring (5,5; 5,6; 5,7) were synthesized. A sulfonamide counterpart of an indolizidinone 2-carboxylic acid was synthesized and evaluated for its activity against the enzyme thrombin.

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Author

Stephen Hanessian; Helen Sailes; Eric Therrien

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4020)

Published

2003

Language

EN

Field

Chemistry (Physical Sciences)