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Can I read CgCaspase-3 activates the translocation of CgGSDME in haemocytes of Pacific oyster Crassostrea gigas on EtoBox?
CgCaspase-3 activates the translocation of CgGSDME in haemocytes of Pacific oyster Crassostrea gigas by Xiaopeng Li; Xiaoxue Yan; Jinyuan Leng; Wei Wang; Yinan Li; Chuanyan Yang; Jiejie Sun; Lingling Wang; Linsheng Song is a Immunology and Microbiology article available to read on EtoBox.
What is CgCaspase-3 activates the translocation of CgGSDME in haemocytes of Pacific oyster Crassostrea gigas about?
Cysteinyl aspartate specific proteinase-3 (Caspase-3) is an important protein involved in the apoptosis and gasdermin E (GSDME)-mediated cell pyroptosis pathways in vertebrates. A Caspase-3 homologue (designated as CgCaspase-3) was previously identified as an immune receptor specific for lipopolysaccharide (LPS) to regulate apoptosis in the Pacific oyster Crassostrea gigas. In the present study, the binding activity of CgCaspase-3 to different pathogen associated molecular patterns (PAMPs) and its effects on CgGSDME translocation in haemocytes were further investigated in C. gigas. The mRNA expression of CgCaspase-3 could be detected in all the tested tissues, including hepatopancreas, labial palp, adductor muscle, gonad, gill, mantle and haemocytes, and it was highly expressed in labial palp, gonad, haemocytes, and adductor muscle. The mRNA expression of CgCaspase-3 in haemocytes increased significantly at 3, 24, 48 and 72 h after LPS stimulation, and it increased significantly at 6, 12, 24 and 48 h after Vibrio splendidus stimulation. The recombinant CgCaspase-3 displayed binding activity towards LPS, mannose (MAN), peptidoglycan (PGN), and polyinosinic-polycytidylic acid potassi
Who reads CgCaspase-3 activates the translocation of CgGSDME in haemocytes of Pacific oyster Crassostrea gigas?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Xiaopeng Li; Xiaoxue Yan; Jinyuan Leng; Wei Wang; Yinan Li; Chuanyan Yang; Jiejie Sun; Lingling Wang; Linsheng Song
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)