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Can I read Increased susceptibility of chronic ulcerative colitis‐induced carcinoma development in DNA repair enzyme Ogg1 deficient mice on EtoBox?
Increased susceptibility of chronic ulcerative colitis‐induced carcinoma development in DNA repair enzyme Ogg1 deficient mice by Jie Liao; Darren N. Seril; Gary G. Lu; Meng Zhang; Shinya Toyokuni; Allison L. Yang; Guang‐Yu Yang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Increased susceptibility of chronic ulcerative colitis‐induced carcinoma development in DNA repair enzyme Ogg1 deficient mice about?
## Abstract Ogg1 DNA repair enzyme recognizes and excises oxidative stress‐caused 8‐hydroxyl‐deoxyguanosine (8‐OHdG) from GC base‐pairs. Ogg1 knockout mice are phenotypically normal, but exhibit elevated levels of 8‐OHdG in nuclear and mitochondrial DNA, as well as moderately elevated mutagenesis and spontaneous lung tumors and UV‐induced skin tumors. To elucidate the mechanistic role of inflammation‐caused oxidative stress in carcinogenesis, the development of chronic ulcerative colitis (UC)‐induced carcinoma in Ogg1 knockout mice was studied using a dextran sulfate sodium (DSS)‐induced UC model without the use of a carcinogen. Ogg1 (−/−), Ogg1 (+/−), and wild type C57BL/6 mice were subjected to long‐term, cyclic DSS treatment to induce chronic UC and carcinogenesis. In wild type C57BL/6 control mice after 15 cycles of DSS treatment, colorectal adenocarcinoma incidence was 24.1% (7/29 mice), with a tumor volume of 27.9 ± 5.2 mm^3^. Ogg1 (−/−) mice showed significantly increased adenocarcinoma development in the colon with a tumor incidence of 57.1% (12 of 21 mice, __P__ < 0.05) and a tumor volume of 35.1 ± 6.1 mm^3^. Ogg1 mice (+/−) also exhibited significantly increased tumor dev
Who reads Increased susceptibility of chronic ulcerative colitis‐induced carcinoma development in DNA repair enzyme Ogg1 deficient mice?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jie Liao; Darren N. Seril; Gary G. Lu; Meng Zhang; Shinya Toyokuni; Allison L. Yang; Guang‐Yu Yang
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)